1. Multiplayer
2. multiple instances of the same script
3. string,bit,byte variables(including globals)
4. per field plugins compared to per record
5. access to the game's formulas through .ESX formats or whatever replaces them
6. modern combat
7. animation and model rework
8. more script commands
9. more customizable small objects filters and other optimizations
10. unhardcode skills and attributes
11. Fps cap
12. other types of currency
13. Synthetic Voice for dialogue
14. no legged races and multi arm etc etc support
no real order to this
Edit1: Formated better
Edit2: summarized