openmw.org

I'll have to see if there's a way for the compiler to tell if it's compiling for a big endian architecture or not. I suspect there is, but haven't looked. If there is, it should be pretty easy to make the changes needed to read nif files on a big endian machine.

There was some work my dougmencken on endian-awareness quite a while ago. I think he had it in a sort-of working state. You might want to check out his fork to see where it's at.
Edit: soft-of -> sort-of

On my other project, WildMIDI, we use Cmake to do Endianess testing and set a define in a common header file.

I think most compilers have certain macros predefined to specify which endian the target system is. I also know for certain that Ogre defines some macros for it.

The cmake approach seems sensible. I'd prefer not to drag in Ogre headers everywhere. They are pretty bloated with other compiler-specific stuff (noticed that the other week when I ran cppcheck and it took hours with testing all the code paths enabled).